Category
Small Molecule CDMOs
Compare small molecule CDMOs for API synthesis, drug product formulation, and finished dosage manufacturing. Filter by chemistry capabilities, scale, and regulatory approvals.
406 companies listed
About Small Molecule Manufacturing
Small molecule manufacturing covers two distinct stages: active pharmaceutical ingredient (API) synthesis and drug product (DP) formulation. API work involves multi-step chemical synthesis, from kilo-lab through pilot-plant to commercial scale. Drug product work transforms the API into tablets, capsules, injectables, or other dosage forms.
Process chemistry is where projects succeed or fail. Look for CDMOs with strong route scouting and process optimization capabilities. A good CDMO can improve yields by 20-40% during scale-up, saving months of development time. Crystallization expertise is particularly critical for controlling polymorphic form and particle size distribution.
How does your CDMO handle potent compounds? Many oncology and hormonal APIs require OEB4 or OEB5 containment. Not every small molecule CDMO has the engineering controls for sub-microgram exposure limits. Verify containment capabilities early -- retrofitting is expensive and slow.
Companies (406)
Tiofarma
Netherlands
Tiofarma is a Dutch CDMO specializing in complex semi-solid formulations (creams and ointments) and emergency nasal sprays, offering services from pre-formulation through commercial supply. The company operates an EU-GMP and FDA-licensed manufacturing facility in Oud-Beijerland, Netherlands, with in-house R&D and analytical laboratories.
Small Molecule Drug ProductOral Solid DoseFormulation Development
T.Man Pharma Company Limited
Thailand
T.Man Pharma Company Limited is a Thai public company established in 1991, specializing in the production and distribution of modern drugs, herbal medicines, food supplements, cosmetics, and health products. With 500-999 employees, the company operates GMP PIC/s certified manufacturing facilities and serves both domestic and international markets. Listed as a CMO/CDMO on CPHI and registered with FDA Thailand.
Small Molecule Drug ProductOral Solid DoseSolid Dose Manufacturing
Frequently Asked Questions
What is the difference between API and drug product manufacturing?+
API (Active Pharmaceutical Ingredient) manufacturing produces the chemical compound that provides therapeutic effect. Drug product manufacturing takes that API and formulates it into the final dosage form patients receive -- tablets, capsules, injectables, creams, etc. Some CDMOs handle both; many specialize in one.
How do you choose a small molecule CDMO?+
Match your project stage to the CDMO's capabilities. Early-phase needs: strong process chemistry and flexibility. Late-phase needs: validated manufacturing, regulatory filing support, and commercial-scale capacity. Check their experience with your reaction types (hydrogenation, cryogenic, high-pressure) and any special handling requirements (potent, controlled substances).
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