PeptiStar Inc.

About

PeptiStar is a Japan-based CDMO specializing in the development and cGMP manufacture of peptide and oligonucleotide APIs. From its 10,500 m² R&D and manufacturing site in Settsu, Osaka, the company supports programs from milligram-scale research material through clinical and commercial production. PeptiStar works with complex peptide structures, including long-chain, cyclic, branched and constrained peptides, non-natural amino acids and peptide conjugates. Its route-flexible manufacturing platform includes conventional and microwave-assisted SPPS, STag-PS and SYNCSOL liquid-phase technologies. Integrated downstream capabilities include preparative and continuous chromatography, membrane concentration and lyophilization, with 300 L filter reactors, chromatography columns up to 450 mm and lyophilizers up to 500 L. Purification and subsequent processing are conducted in Class 100,000 controlled areas. PeptiStar also develops and manufactures oligonucleotide APIs and peptide–oligonucleotide conjugates. The company was recognised by Exelixis as its 2025 CDMO of the Year.

Key Expertise

• Complex peptide API development • Long-chain peptides over 100 amino acids • Cyclic and constrained peptides • Non-natural amino acids • Branched and dimeric peptides • Peptide conjugates • Peptide–oligonucleotide conjugates • Oligonucleotide API manufacturing • Microwave-assisted SPPS • Conventional SPPS • LPPS • STag-PS • SYNCSOL • Continuous chromatography • HILIC purification • API lyophilisation • Clinical and commercial cGMP supply • Process development and scale-up

Therapeutic Areas