Small Molecule API CDMOs

Fisher BioServices (Thermo Fisher)

Netherlands

Fisher BioServices is part of Thermo Fisher Scientific's Patheon pharma services division, one of the world's largest CDMOs offering end-to-end 360-degree CDMO and CRO solutions. The Patheon platform covers drug substance and drug product manufacturing for small molecules, large molecules, and advanced therapies, along with clinical supply and commercialization services.

SOMAI Pharmaceuticals is a Portuguese EU-GMP certified vertically integrated Multi-Country Operator (MCO) specializing in the manufacturing of medical-grade cannabis APIs and oral solutions. The company holds INFRAMED authorization for its Lisbon facility and has partnerships for distribution in the German market.

Guobang Pharmaceutical Group is a global pharmaceutical manufacturing company based in Zhejiang, China, and is among China's top 100 pharmaceutical enterprises. The company specializes in APIs, key pharmaceutical intermediates, and formulations for both human and veterinary health, with products sold to over 115 countries and regions. Founded in 1996, the company employs over 4,000 people across 2,500+ acres of operational land.

Adesis Inc

United States

Adesis Inc is a US-based CDMO and chemistry solutions company, a subsidiary of Universal Display Corporation (Nasdaq: OLED). With approximately 80% PhD scientists on their R&D team, they provide discovery chemistry, process chemistry, specialty manufacturing, and custom peptide synthesis services across 100,000 sq ft of lab, manufacturing, and client services space. All facilities are 100% US-based.

Deretil S.A.

Spain

Deretil is a Spanish company with over 50 years of experience in pharmaceutical raw material manufacturing, operating as a Contract Manufacturing Organisation. They specialize in the development and manufacture of side chains for beta-lactam antibiotics, including Amoxicillin and related intermediates, integrating production from raw material phases through final API products.

Srikem Laboratories Pvt Ltd

India

Srikem Laboratories Pvt Ltd is an Indian pharmaceutical company based in Navi Mumbai (MIDC Taloja industrial area) that manufactures active pharmaceutical ingredients. Search results indicate they supply APIs including Clotrimazole and antibacterials for systemic use. No website text was available. They are listed on PharmaSource and appear in a Global Business Reports feature on India Pharmaceuticals as investing in R&D and manufacturing capabilities. Limited information prevents a more detailed classification, but evidence points to API manufacturing rather than contract drug product manufacturing.

Biofer S.p.A.

Italy

Biofer S.p.A. is an independent Italian pharmaceutical company specializing in the manufacture of Active Pharmaceutical Ingredients (APIs) for nearly 40 years. Core products include iron complexes (antianemics), heparin and glycosaminoglycans, steroids, enzymes, and folinates. The company operates under strict GMP standards with an emphasis on quality, safety, and efficacy. FDA-registered with 3 inspections (0 NAI, 3 VAI).

DUPLICATE ENTRY: This is the same company as Sri Krishna Pharmaceuticals Ltd (companyId: 12028a28). SKPL was established in 1974 and specializes in bulk manufacture of APIs, DC granules, and finished dosage forms. See primary entry for full profile.

Chengdu Okay Pharmaceutical Co., Ltd. is a Chinese high-tech enterprise offering APIs, intermediates, and plant extracts. The company provides CDMO capabilities including chemosynthesis and API process development for domestic and international pharmaceutical clients.

Chemspec‑API Inc.

Canada

Chemspec-API Inc. is a US-based API manufacturer formed as a joint venture between Shanghai Chemspec Corp. and API Inc., providing clients with FDA-compliant manufacturing of APIs and pharmaceutical intermediates. The company offers custom synthesis, process development, and contract manufacturing services with access to extensive resources at Shanghai Chemspec.

Chongqing Southwest No.2 Pharmaceutical Factory Co., Ltd. is a Chinese pharmaceutical manufacturer with an FDA-registered 3,600 sq.m. facility producing innovative APIs. The company has connections to Porton Pharma's leadership and appears in industry reports as a small molecule API manufacturer.

Hapila GmbH

Germany

Hapila GmbH is an independent chemical-pharmaceutical CDMO based in Gera, Thuringia, Germany, specializing in the development and GMP manufacturing of active pharmaceutical ingredients, including high-potency APIs. The company provides services from early development through to market supply for approved medicinal products.

Envee Drugs Pvt. Ltd.

India

Envee Drugs Pvt. Ltd. is an Indian API manufacturer located in Gujarat, India, producing small molecule active pharmaceutical ingredients including hydrocortisone, clobetasol propionate, and other steroid and dermatological APIs. The company supplies APIs to pharmaceutical companies globally.

HealthTech BioActives (HTBA)

Spain

HealthTech BioActives (HTBA) is a Spanish company and global leader in citrus flavonoids and Vitamin B12 active forms, with over 45 years of experience. The company specializes in the clean production of naturally sourced active pharmaceutical ingredients and nutraceutical ingredients from its manufacturing facilities in Murcia, Spain.

Eskay Iodine Pvt Ltd

India

Eskay Iodine Pvt Ltd is an Indian API manufacturer registered with the FDA (FEI 3010331979) for API manufacturing. The company is part of the S Kant Healthcare group and has received clean FDA inspection results with 2 NAI outcomes.

Flow Eighteen38 is a protein sciences division within the FairJourney Biologics Group, based in Portugal, providing antibody characterization, protein production, and biophysical analysis services. It received 5 million euros to expand production and biophysical capabilities, serving the drug discovery and research community.

Steroid S.p.A.

Italy

Steroid S.p.A. is one of the oldest privately-owned steroid API manufacturing companies, founded in the early 1950s in Italy. The company specializes in the synthesis of steroid esters including corticosteroids, progestinics, hormones, anabolics, and estrogens for both human and veterinary use, with over 15 tons installed capacity.

Hainan Haiyao Co., Ltd

China

Hainan Haiyao Co., Ltd. is a Chinese pharmaceutical enterprise founded in 1965 that integrates R&D, production, and sales of traditional Chinese medicine and chemical APIs. The company is FDA-registered and has undergone FDA inspections. It supplies APIs and pharmaceutical products including D-Glucosamine Sulfate and Paclitaxel to domestic and international markets.

Hamari Chemicals Ltd

Japan

Hamari Chemicals, Ltd., established in 1948 and headquartered in Japan, is a global provider of custom chemical manufacturing services to the pharmaceutical industry. The company manufactures APIs at its GMP facility in Saito, Ibaraki City, Osaka, and has FDA-registered and inspected facilities. It serves as a CDMO for small molecule APIs.

Hebei Jiheng Pharmaceutical Co., Ltd. is a Chinese API manufacturer and supplier specializing in Paracetamol (Acetaminophen) and related pharmaceutical ingredients. The company holds DMF and CEP certifications and is FDA-registered with multiple FEI numbers.

Huanggang LUBAN Pharmaceutical Co., Ltd. is a Chinese pharmaceutical company that manufactures APIs and intermediates, specializing in chiral intermediates and fine chemicals. The company is FDA-registered and participates in the contract small molecule API manufacturing industry.

Hubei Biocause Heilen Pharmaceutical Co., Ltd. is a Chinese pharmaceutical company based in Jingmen City, manufacturing active pharmaceutical ingredients including fludarabine phosphate, ibuprofen, and other APIs. The company is FDA-registered and has undergone multiple FDA inspections. It also offers contract manufacturing services.

IMS srl Micronizzazioni is an Italian company based in Milan specializing in the micronization of active pharmaceutical ingredients (APIs) and excipients on behalf of third parties. The company has been inspected by the FDA multiple times (6 inspections, most recently in May 2024) and is positioned as a strategic partner in pharmaceutical micronization and controlled drug release.

Keshava Organics Pvt Ltd

India

Keshava Organics Pvt Ltd is an Indian API manufacturer with a facility at MIDC Tarapur. They produce active pharmaceutical ingredients including brompheniramine maleate and other small molecule APIs. The company holds US DMF filings, has CDSCO registration, and is listed as an API supplier on CPHI. Their FDA-registered facility (FEI 3003677831) has had 4 inspections with 2 VAI and 2 OAI outcomes. They produce generic APIs and intermediates for the pharmaceutical industry.

Sunny Pharmtech Inc. is a Taiwan-headquartered integrated specialty pharmaceutical CDMO specializing in high-potency APIs and drugs, including small molecules, peptides, and ADC linker-payloads. The company develops complex, high-barrier, niche drugs including ANDAs and 505(b)(2) filings, with state-of-the-art facilities offering OEB 5 containment and capabilities from early-stage formulation development to commercial manufacturing.

Kirsch Pharma HealthCare GmbH is a German company focused on pharmaceutical raw materials sourcing and production, and production technologies (refining and mixing). Their website indicates services in pharmaceutical sourcing and production of raw materials. A related entity, Kirsch BioPharm, appears to be building biopharma manufacturing capabilities, but Kirsch Pharma HealthCare itself is primarily a pharmaceutical raw material and excipient supplier rather than a CDMO. Without website text or detailed evidence of contract drug manufacturing, they are classified as a raw material supplier.

Heraeus Precious Metals GmbH & Co. KG

Germany

Heraeus Precious Metals GmbH & Co. KG is the pharmaceutical ingredients division of the Heraeus Group, specializing in the production of generic highly potent active pharmaceutical ingredients (HPAPIs) for cancer treatment. The company is the global market leader for platinum-based active ingredients including cisplatin, carboplatin, and oxaliplatin. In 2021, Heraeus made a multi-million euro investment expanding HPAPI manufacturing capacity in Hanau, Germany.

Symbiotec Pharmalab is a leading Indian manufacturer of corticosteroid and steroidal-hormone APIs with a global leadership position. With over 30 years of experience, the company has evolved from lab-scale manufacturing to industrial-scale production, operating two FDA-approved facilities (Rau and Pithampur, Indore). The company offers integrated CDMO solutions across organic chemistry, biotechnology/fermentation, and complex injectable platforms. It holds a 50%+ global market share in key steroid API molecules and serves 200+ customers in 40+ countries.

NAM Group of Industries Pvt. Ltd.

India

Indian WHO-GMP certified manufacturer and exporter of pharmaceutical active pharmaceutical ingredients (APIs) for human and veterinary use, plus pharmaceutical intermediates and phase transfer catalysts. Not a contract manufacturer -- produces and sells own API portfolio. Headquartered in Mumbai with manufacturing plant in Ankleshwar, Gujarat. Facility covers 5,000 sqm with dedicated clean rooms for human and veterinary APIs.

Symphony Pharma Life Sciences Pvt Ltd

India

Symphony Pharma Life Sciences is a CRO and CDMO based in Hyderabad, India, founded in 2008 by research-driven scientists. The company operates a 25,000+ sq. ft. research facility in Genome Valley, providing contract research, custom synthesis, and contract development and manufacturing services. Symphony has executed 40+ NCE intermediate projects for global innovator companies, developed 8 new APIs (including Lacosamide with USFDA-approved DMF), and synthesized 250+ API impurities for global MNCs.

Synergene Active Ingredients Private Limited

India

Synergene Active Ingredients is a fast-growing Indian API manufacturer incorporated in 2006, with 40 years of industrial experience and 800+ employees. The company manufactures 30+ APIs serving 300+ customers in 50+ countries. Synergene operates four manufacturing units in Hyderabad and Visakhapatnam with combined production capacity of 800+ KL (plus 700 KL under installation). The company has CEPs from EDQM, US DMFs, Japanese DMFs, ANVISA CBPF, and WHO GMP certifications. Synergene also produces specialty chemicals for skincare, sun care, and haircare applications.

Syn-Tech Chem & Pharm Co. Ltd

Taiwan

Syn-Tech Chem & Pharm Co. Ltd is a Taiwanese API manufacturer established over 30 years ago, providing good quality APIs to customers worldwide including USA, Japan, Korea, and Europe. The company has passed multiple regulatory audits and holds PMDA, US FDA, KFDA, and TFDA approvals. Syn-Tech is expanding its CDMO capabilities and manufactures APIs such as guanfacine HCl and crotamiton. The company won the 2003 National Biotechnology and Medical Quality Award in Taiwan.

Exemed Pharmaceuticals

India

Exemed Pharmaceuticals is an Indian pharmaceutical company established in 2009, with US FDA, EDQM, and EU GMP certified manufacturing facilities in Vadodara and Vapi, Gujarat. The company manufactures APIs including Metformin HCL, Allopurinol, Levetiracetam, and Vildagliptin, and also has a finished formulation manufacturing facility acquired from UCB India.

Vijayasri Organics Private Limited

India

Vijayasri Organics Private Limited is an India-based pharmaceutical API manufacturer with FDA registration (FEI numbers 3008408466 and 3009451765). The company has manufacturing facilities and supplies APIs globally. FDA inspection history shows 3 inspections (1 NAI, 2 VAI, latest June 2024), indicating active regulatory compliance. No website content available (site appears to be down), but search results and FDA records confirm API manufacturing operations from Visakhapatnam, India.

Star Lake Bioscience Co., Inc. Zhaoqing Guangdong is a Chinese bioscience company founded in 1964 in Zhaoqing, Guangdong Province. They manufacture APIs and pharmaceutical intermediates including ribavirin and inosine. They are listed on CPHI Online as offering generic APIs and appear at major pharma trade shows (CPhI China). Their primary business appears to be API/intermediate production and supply rather than contract drug product manufacturing. They started as a small factory and have grown into a supplier of pharmaceutical ingredients.

Huayi Pharmaceutical (Anhui) Co., Ltd. is an EU cGMP-approved Sino-British joint venture CDMO located in Hefei, Eastern China. The company specializes in contract development and manufacturing of high-quality generic pharmaceuticals across various dosage forms, offering integrated services from API production through finished dosage form manufacturing.

Hygro Chemicals Pharmtek Pvt Ltd.

India

Hy-Gro Chemicals Pharmtek Pvt Ltd. is an Indian manufacturer of high-quality APIs and advanced intermediates with two cGMP-compliant manufacturing facilities. The company offers CRAMS services and specializes in multi-step chemical synthesis, with approvals from USFDA, EDQM, PMDA, and KFDA (MFDS).

Topharman Shanghai Co., Ltd. is a Chinese contract services company established in 2000, offering pharmaceutical R&D solutions including synthetic chemistry, process development, and CMO/CDMO services for APIs. The company provides custom synthesis and manufacturing services to global pharmaceutical partners.

Xi'an Wanlong Pharmaceutical

China

Xi'an Wanlong Pharmaceutical Co., Ltd. is a comprehensive modern pharmaceutical enterprise founded in 1995, primarily producing formulations, APIs, and intermediates with GMP and DMF compliance. The Yangling facility spans 200,000 sq.m. with 18 production lines for injections, tablets, capsules, powder, and raw materials.

LinkChem Co., Ltd. is a Chinese high-tech enterprise founded in 2011, providing professional CDMO/CMO/CRO services for pharmaceutical companies. The company, part of the Linkchem Group (including Chemenu), specializes in custom synthesis of pharmaceutical intermediates and APIs from R&D to commercial scale manufacturing.

Ingenza Ltd

United Kingdom

Ingenza Ltd is a UK-based full-service protein CRDMO (Contract Research, Development and Manufacturing Organisation) headquartered in Edinburgh, Scotland. With over 20 years of experience, the company specializes in engineering biology for biologics and small molecule pharmaceuticals, offering services from drug discovery through pre-clinical manufacturing. Ingenza has a 100% success rate producing customer targets and has produced over 7,000 strains/cell-lines and proteins. GMP capability is coming online in Q2 2026.

InnoSyn BV

Netherlands

InnoSyn BV is a Dutch custom synthesis and process optimization company spun out from DSM's chemical process R&D group. With over 30 years of expertise, the company specializes in route scouting, process safety, flow chemistry, crystallization, and biocatalysis. InnoSyn operates a versatile multi-purpose pilot plant and offers services from lab recipe to industrial-scale production, serving pharma and chemical industries.

Intas Pharmaceuticals

India

Intas Pharmaceuticals is a leading vertically integrated pharmaceutical company headquartered in Ahmedabad, India, with CDMO capabilities spanning API manufacturing through finished formulations. The company operates 14 manufacturing facilities globally (11 in India, plus UK and Mexico), serving 85+ countries with particular strength in oncology, biosimilars, and plasma-derived therapies. Its flagship Pharmez 2 facility can produce over 1 billion solid oral units monthly and 5 million injectable units.

Interquim Mexico (Interquim, S.A. de C.V.)

Mexico

Interquim, S.A. de C.V. is a Mexico-based API manufacturer with extensive FDA registration (58 FEI numbers) and a long history of FDA inspections including 88 total inspections. The company has experienced 9 OAI findings and 5 recalls including 4 Class I recalls, indicating significant scale but also regulatory compliance challenges.

GENSENTA

Turkey

Gensenta (formerly Mustafa Nevzat Ilac, acquired by Amgen in 2012 and sold to Eczacibasi in 2020) is a vertically integrated Turkish pharmaceutical company with two manufacturing facilities in Yenibosna and Sekerpinar, Turkey. The company manufactures both drug products and raw materials (APIs), and has been recognized in the sterile injectable CDMO market. Gensenta is listed as part of the Eczacibasi group and produces pharmaceuticals including caspofungin.

Jeil Pharmaceutical Co., Ltd.

South Korea

Jeil Pharmaceutical Co., Ltd. is a South Korean pharmaceutical company headquartered in Seoul that offers APIs, finished dosage products, and CMO services. The company has a production capacity of 1.5 billion oral dosage units per year and manufactures tablets, transdermal patches, and other dosage forms. Jeil supplies 62 products including APIs, excipients, and intermediates and is FDA-registered.

Pierre Fabre (CDMO)

France

Pierre Fabre CDMO is the contract development and manufacturing arm of the Pierre Fabre Group, a French pharmaceutical and dermo-cosmetics company. Offers over 20 years of CDMO services across pharma and non-pharma active ingredients, dry forms, non-sterile liquids, and biologics including monoclonal antibodies and ADCs. Operates R&D site in Toulouse and 3+ industrial sites in France. Expertise spans extraction, chromatographic purification, chemical synthesis, cytotoxic compound production, plant cell culture, and supercritical CO2 technology. Manufactures 2,100 metric tons of plant extracts and 100+ active ingredients annually.

Grünenthal PRO (Grünenthal CDMO)

Chile

Duplicate entry of Grunenthal PRO (company ID 8756785b). Grunenthal PRO is the contract manufacturing arm of Grunenthal Group, operating five specialized plants with vertically integrated manufacturing from active substance to finished products. Approximately 50% of total production is for third-party clients across 100+ countries.